Research Information System
Turkish Journal of Surgery, vol.35, no.2, pp.61-69, 2005 (Scopus)
ABSTRACT Until today, a widely accepted treatment approach has not yet been defined for metastatic breast cancer. A noncomparative, non-interventional observational study was conducted to evaluate first-line systemic treatment approaches in metastatic breast cancer patients in Turkey. A total of 372 metastatic breast cancer patients from 34 institutes were taken into the study. Median age at diagnosis was 50 (21-84). Sixty-five percent of the patients were postmenopausal. Thirty percent were metastatic at first admission, the median time to metastasis for the rest was 28.5 months (3-205). Hormone receptor status was evaluated in 71% of patients and 57% were found receptor (+). Hormonal therapy was not considered in first-line for 32% of receptor (+) patients. For patients who were metastatic at first admission, anthracycline-based regimens were the most common choice of treatment as first-line. Overall in the first-line, taxanes were preferred for 13% and 8% of premenopausal and postmenopausal patients, respectively. Receptor status was found to significantly affect the choice of treatment for all subgroups, while age of onset and site of metastasis were significant for only postmenopausal patients.[Turk J Cancer 2005;35(2):61-69].
ACKNOWLEDGEMENTS
We would like to thank the following physicians who participated in the study (in alphabetical order):Ali Osman Sönmez
Oncology Hospital, Department of Radiation Oncology: Günay Tanlak, İbrahim Yıldırım; Adana SSK Hospital, Department of Medical Oncology: Aynur Eken; Adnan
Menderes University Medical School, Department of Medical Oncology: Sabri Barutça, Nezih Meydan; Akdeniz University Medical School, Department of Medical Oncology:
Mustafa Özdoğan, Mustafa Samur; Ankara Gülhane Military Medical Academy, Department of Medical Oncology: Fikret Arpacı, Şeref Kömürcü, Ahmet Özet, Bekir Öztürk;
Ankara Numune Training and Research Hospital, Department of Medical Oncology: Nurullah Zengin; Ankara Oncology Training and Research Hospital, Department of
Medical Oncology: Necati Alkış; Ankara University Medical School, Department of Medical Oncology: Abdullah Büyükçelik, Fikri İçli; Atatürk Training and Research
Hospital, Department of Radiation Oncology: Merih Şan; Atatürk University Medical School, Department of Medical Oncology: Salim Başol Tekin; Çukurova University
Medical School, Department of Medical Oncology: Umut Dişel, Melek Erkişi, Sinan Yavuz; Dicle University Medical School, Department of General Surgery: İbrahim
Taçyıldız; Dokuz Eylül University Medical School, Department of Medical Oncology: Mehmet Alakavuklar, Binnaz Demirkan; Dokuz Eylül University Medical School,
Department of Radiation Oncology: Hilmi Feyzi Alanyalı; Ege University Medical School, Department of Medical Oncology: Erdem Göker, Bülent Karabulut, Canfeza
Sezgin; Erciyes University Medical School, Department of Medical Oncology: Mustafa Altınbaş; Gaziantep University Medical School, Department of Medical Oncology:
Celalettin Camcı, Mehmet Türk; Hacettepe University Medical School, Department of Medical Oncology: Nilüfer Güler; İstanbul Çamlıca Gülhane Military Medical Academy,
Department of Medical Oncology: Gökhan Kandemir, Mustafa Yaylacı; İstanbul University Cerrahpaşa Medical School, Department of Radiation Oncology: Nuran Şenel
Beşe, Ahmet Öber; İstanbul University Cerrahpaşa Medical School, Department of Medical Oncology: Hande Savaş, Süheyla Serdengeçti; İstanbul University İstanbul
Medical School, Department of Medical Oncology: Adnan Aydıner, Erkan Topuz; Kartal Lütfi Kırdar Training and Research Hospital, Department of Medical Oncology:
Mehmet Aliustaoğlu, Mahmut Gümüş, Taflan Salepçi; Kartal Lütfi Kırdar Training and Research Hospital, Department of Radiation Oncology: Cengiz Gemici, Orhan
Kızılkaya, Alpaslan Mayadağlı; Mamer Surgery Center, Bursa: Erol Aksaz, Güven Atasoy, Ceyhun İrgil, Tayanç Öncel; Marmara University Medical School, Department
of Medical Oncology: Serdar Turhal; Metropolitan Florence Nightingale Hospital, Department of Medical Oncology: Coşkun Tecimer, Necdet Üskent; Ondokuz Mayıs
University Medical School, Department of Medical Oncology: İdris Yücel; SSK İzmir Training and Research Hospital, Department of General Surgery: Baha Zengel; SSK
Okmeydanı Training and Research Hospital, Department of Radiation Oncology: Ömür Alan, Binnur Dönmez, Mustafa Ünsal; SSK Tepecik Hospital, Department of General
Surgery: Ragıp Kayar; T.K.V. Levent Medical Center, Department of Medical Oncology: Metin Aran; Trakya University Medical School, Department of Medical Oncology:
Kazım Uygun; Vakıf Gureba Hospital, Department of Medical Oncology: Gülistan Köksal; AstraZeneca, Turkey: Rasih Altay, Süleyman Kentli, Uğur Tepe