Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury


ARSLAN M., ÇOMU F. M. , KÜÇÜK A., ÖZTÜRK L., YAYLAK F.

LIBYAN JOURNAL OF MEDICINE, vol.7, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2012
  • Doi Number: 10.3402/ljm.v7i0.18185
  • Journal Name: LIBYAN JOURNAL OF MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: hepatic ischemia-reperfusion injury, lipid peroxidation, malondialdehyde, superoxide dismutase, erythrocyte deformability, dexmedetomidine, ISCHEMIA/REPERFUSION INJURY, NITRIC-OXIDE, DAMAGE, RATS, MECHANISMS, ANESTHESIA, EXPRESSION, APOPTOSIS, SURGERY

Abstract

Background: Hepatic ischemia-reperfusion injury is a common clinical problem in hepatic surgery and transplantation. Several cellular and tissue structural and functional alterations are observed in such injury. The aim of this study was to evaluate the effect of dexmedetomidine on lipid peroxidation and erythrocyte deformability during ischemia-reperfusion injury in rats.