Research Information System
ZEYNEP KAMİL TIP BÜLTENİ, vol.49, no.1, pp.136-139, 2018 (Peer-Reviewed Journal)
Objective: To assess the effects of serum and follicular
fluid total oxidant (TOC) levels, total antioxidant capacity (TAC), and oxidative stress index (OSI) on oocyte
maturation, fertilization, embryogenesis, and clinical
pregnancy outcomes in In Vitro Fertilization (IVF) cycles
of infertile patients.
Material and Methods: One hundred patients having infertility and underwent ART enrolled the study group and
blood samples were collected on gonadotropin starting,
oocyte pick-up (OPU) and embryo transfer (ET) days.
Additionally, follicular fluid specimen obtained during
OPU was collected. TOC, TAC levels and OSI in serum
samples and follicular fluid specimens between clinically
pregnant and non-pregnant patients were compared.
Results: No significant difference was noted between clinically pregnant and nonpregnant patients in terms of the
woman’s age, duration of infertility, ovarian reserve or
number of transferred embryos. There was also no significant difference in TAC, TOC and OSI levels in serum
samples obtained during three phases of treatment cycle
(basal gonadotropin starting day, OPU day and ET day)
and in follicular fluid samples.
Conclusion: TAC, TOC and OSI seem to be ineffective to
predict clinical pregnancy as an outcome in patients who
underwent ART.
Keywords: infertility, iotal oxidant capacity, total antioxidant capacity, oxidative stress index