The relationship of lactate levels with carboxyhemoglobin levels and clinical findings in patients admitted with acute carbon monoxide poisoning Akut karbon monoksit zehirlenmesiyle başvuran hastaların laktat düzeyinin karboksihemoglobin ve klinik bulgularla ilişkisi

Usul E., Halici A., Höke M. H.

Duzce Medical Journal, vol.23, no.1, pp.41-46, 2021 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.18678/dtfd.844904
  • Journal Name: Duzce Medical Journal
  • Journal Indexes: Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.41-46
  • Keywords: Carbon monoxide, Carboxyhemoglobin, Hyperbaric oxygenation, Lactate, Poisoning
  • Kütahya Health Sciences University Affiliated: No


Aim: Acute carbon monoxide (CO) poisoning is a potentially mortal, though preventable, condition. Mild poisoning presents with non-specific symptoms, such as fatigue, headache, nausea and vomiting, whereas severe exposure to CO can result in loss of consciousness, coma, and death. The aim of this study was to investigate the utility of lactate and carboxyhemoglobin (COHb) levels in the clinical presentation and treatment of patients with acute CO poisoning. Material and Methods: Data were obtained from the hospital information system and patient files with ICD-10 code “T58: Toxic effects of CO”. The blood parameters and vital signs of patients at admission, causes of poisoning, time to hospital, and Glasgow coma scores during admission were recorded. Within related and relevant complications of CO intoxication and data concerning treatment plans and hospitalization status were recorded. Results: A statistically significant difference was found between COHb and lactate levels of patients who did and did not develop neurological and cardiac complications (p<0.001). Moreover, a statistically significant difference was found in COHb and lactate levels among patients who did or did not receive hyperbaric oxygen therapy, and who were hospitalized or not (p<0.001). As looking for biochemical profile, significant correlations was found between COHb and pH, base excess, and bicarbonate and lactate levels. Conclusion: This study shows that COHb and lactate levels at admission to the emergency department are significant for prognosis, follow-up, and treatment of patients with CO poisoning. Elevated lactate and COHb levels may also found to be associated with neurological and cardiac complications.