The Effects of Dietary and Exercise Therapy on Some Biochemical Parameters and Semaphorin 3E in Obese and Non-Obese Patients

Uslu S., Sezgin G., Kar F., Dinçer Öner K. S.

Clinical Chemistry And Laboratory Medicine, vol.56, no.11, pp.75-76, 2018 (SCI-Expanded)

  • Publication Type: Article / Abstract
  • Volume: 56 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.1515/cclm-2018-1038
  • Journal Name: Clinical Chemistry And Laboratory Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.75-76
  • Kütahya Health Sciences University Affiliated: No

Abstract

Objective: In this study, we aimed to examine the effects of dietary and exercise therapy on some biochemical parameters and SEMA 3E in obese and non-obese patients Material and Methods: 37 patients who applied for Eskişehir Private Fora Physical Therapy and Rehabilitation Center between 01.11.2017- 30.05.2018 were included in the study. Patients were divided into 3 groups according to body mass index (BMI) and diet and exercise therapy were applied for 8 weeks. Fasting blood glucose, triglyceride, total cholesterol, HDL, LDL, HsCRP, fasting insulin levels were measured with Rosche COBAS C501 autoanalyzer in Eskisehir Osmangazi University Clinical Biochemistry Laboratory. Semaphorin-3E and Plexin-D1 serum levels were measured by enzyme-linked immunosorbent assay (ELISA). All values were evaluated before and after treatment. Results: There was a statistically significant difference between fasting blood glucose and triglyceride levels measured at the beginning of the study and the values measured at the end of the 8-week diet and exercise treatment respectively (p < 0.05), (p < 0.001). Although there was a statistically significant difference in the measured glucose values between the groups (p < 0.05), there was no statistically significant difference between the groups in triglyceride values. (p > 0.05). There was a statistically significant difference between the fasting insulin values 13.07 ± 6.11 and 9,53 ± 5.82 (p < 0.001) and the HOMA-IR values 2.98 ± 1.63 and 2.15 ± 1.63 (p < 0.001) measured at the beginning of the study and at the end of 8 weeks. There were no significant differences in the triglyceride, HDL, HOMA-IR values between the groups according to BMI values. The HsCRP level showed a statistically significant difference between the groups according to the degree of obesity (p < 0.05). However, there was no statistically significant difference in HsCRP value as a result of diet and exercise treatment (p > 0.05).There was a statistically significant difference between the beginning of the study and the SEMA 3E values measured after 8 weeks of diet and exercise therapy (p < 0.05). However, there was no statistically significant difference between the Sema3E values among the groups (p > 0.05). There was no statistically significant relationship between insulin resistance and SEMA 3E levels (p > 0.05). There was no statistically significant difference between the beginning of the study and the Plexin D1 values measured at the end of the 8-week diet and exercise treatment (p > 0.05). Conclusion: According to our results, fasting blood glucose, triglycerides, HOMA-IR values of both obese and non-obese patients were reduced as a result of diet and exercise therapy. HDL levels increased with diet and exercise therapy regardless of body mass index. Sema3E levels increased after 8 weeks of treatment regardless of body mass index. We can say that SEMA 3E levels may be increased by a protective mechanism to reduce insulin resistance. Keywords: Obesity, İnsulin resistance, SEMA 3E, Plexin D1