Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model


Inal S. , Kabay S. , Cayci M. K. , Kuru H. İ. , Altikat S. , Akkas G. , et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, cilt.45, ss.494-500, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.injury.2013.10.002
  • Dergi Adı: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Sayfa Sayısı: ss.494-500

Özet

Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are particularly used in patients with bone fractures, but there are limited studies on whether one NSAID is superior to another. In this study, we used histopathological and biochemical parameters to determine whether there are differences between the effects of the administration of clinical doses of dexketoprofen trometamol (DEXT), meloxicam (MEL) and diclofenac sodium (DIC) on the healing of closed fibular fractures and the toxicity of both the liver and kidney.