Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model


Inal S. , Kabay S. , Cayci M. K. , Kuru H. İ. , Altikat S. , Akkas G. , ...More

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.45, no.3, pp.494-500, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1016/j.injury.2013.10.002
  • Title of Journal : INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Page Numbers: pp.494-500
  • Keywords: Fracture healing, Anti-inflammatory agents, Non-steroidal, Liver, Kidney, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, PROSTAGLANDIN E-2, OXIDATIVE STRESS, IN-VIVO, BONE, NEPHROTOXICITY, TENOXICAM, NAPROXEN, IMPACT, CELLS

Abstract

Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are particularly used in patients with bone fractures, but there are limited studies on whether one NSAID is superior to another. In this study, we used histopathological and biochemical parameters to determine whether there are differences between the effects of the administration of clinical doses of dexketoprofen trometamol (DEXT), meloxicam (MEL) and diclofenac sodium (DIC) on the healing of closed fibular fractures and the toxicity of both the liver and kidney.