Secretomes reveal several novel proteins as well as TGF-beta 1 as the top upstream regulator of metastatic process in breast cancer

ERİN N., Ogan N., YERLİKAYA A.

BREAST CANCER RESEARCH AND TREATMENT, vol.170, no.2, pp.235-250, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 170 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1007/s10549-018-4752-8
  • Journal Name: BREAST CANCER RESEARCH AND TREATMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.235-250
  • Keywords: Breast cancer, Proteomic, Fibulin-4, BMP-1, MMP, TGF-beta 1, Liver metastasis, Brain metastasis, MATRIX METALLOPROTEINASES MMP-2, THYMIC STROMAL LYMPHOPOIETIN, SENSORY NEURONS PROMOTES, GROWTH-FACTOR-BETA, GENE-EXPRESSION, N-CADHERIN, ANNEXIN A1, TGF-BETA, MESENCHYMAL TRANSITION, COLORECTAL-CANCER
  • Kütahya Health Sciences University Affiliated: No

Abstract

Metastatic breast cancer is resistant to many conventional treatments and novel therapeutic targets are needed. We previously isolated subsets of 4T1 murine breast cancer cells which metastasized to liver (4TLM), brain (4TBM), and heart (4THM). Among these cells, 4TLM is the most aggressive one, demonstrating mesenchymal phenotype. Here we compared secreted proteins from 4TLM, 4TBM, and 4THM cells and compared with that of hardly metastatic 67NR cells to detect differentially secreted factors involved in organ-specific metastasis.