Secretomes reveal several novel proteins as well as TGF-beta 1 as the top upstream regulator of metastatic process in breast cancer


ERİN N., Ogan N., YERLİKAYA A.

BREAST CANCER RESEARCH AND TREATMENT, cilt.170, ss.235-250, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 170 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s10549-018-4752-8
  • Dergi Adı: BREAST CANCER RESEARCH AND TREATMENT
  • Sayfa Sayıları: ss.235-250

Özet

Metastatic breast cancer is resistant to many conventional treatments and novel therapeutic targets are needed. We previously isolated subsets of 4T1 murine breast cancer cells which metastasized to liver (4TLM), brain (4TBM), and heart (4THM). Among these cells, 4TLM is the most aggressive one, demonstrating mesenchymal phenotype. Here we compared secreted proteins from 4TLM, 4TBM, and 4THM cells and compared with that of hardly metastatic 67NR cells to detect differentially secreted factors involved in organ-specific metastasis.