A study of the possible association of plasminogen activator inhibitor type 1 4G/5G insertion/deletion polymorphism with susceptibility to schizophrenia and in its subtypes


Yenilmez C., Koroglu Z. O. , Kurt H., Yanas M., Colak E., Degirmenci I. , ...More

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, vol.42, no.1, pp.103-107, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1111/jcpt.12470
  • Title of Journal : JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
  • Page Numbers: pp.103-107

Abstract

What is known and objectiveInhibition of the fibrinolytic system may occur at the level of plasminogen activation, mainly by PAI-1. Mental and physical stress caused to alterations of platelet function, and also decreased to fibrinolytic activity. Furthermore, stress-induced thrombosis regulation was proposed to be by PAI-1 in schizophrenia patients. In this study, the distribution of genotypes and frequency of alleles of the plasminogen activator inhibitor type 1 (PAI-1) gene 4G/5G polymorphism in different Turkish clinical schizophrenia subtypes was investigated for its role in schizophrenia development.