Does ketogenic diet have any negative effect on cardiac systolic and diastolic functions in children with intractable epilepsy?: One-year follow-up results

Ozdemir R. , Kucuk M., Guzel O., Karadeniz C., Yilmaz U., Mese T.

BRAIN & DEVELOPMENT, vol.38, no.9, pp.842-847, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.1016/j.braindev.2016.03.009
  • Title of Journal : BRAIN & DEVELOPMENT
  • Page Numbers: pp.842-847


Objective: The ketogenic diet (KD) has been referred to as an "effective therapy with side effects" for children with intractable epilepsy. Among the most recognized adverse effects, there are cardiac conduction abnormalities, vascular and myocardial dysfunction. However, very limited and controversial data are available regarding the effects of the KD on cardiac functions. We sought to analyze the mid-term effect of ketogenic diet on cardiac functions in patients with intractable epilepsy who received a ketogenic diet for at least 12 months using conventional and relatively new imaging techniques.